Beilstein J. Org. Chem.2020,16, 1853–1862, doi:10.3762/bjoc.16.152
site of GlfT2, none of these compounds serve as efficient inhibitors of the enzymes involved in the mycobacterial galactan biosynthesis.
Keywords: GlfT2; molecular modeling; mycobacterium tuberculosis; synthesis; transitionstateinhibitors; Introduction
Tuberculosis (TB) is one of the most prevalent
-acetylglucosaminyltransferase I (GnT-I) reaction transition state [11]. Previously, we have designed 2-thiohexofuranoside skeletons bearing a phosphate group in position 1 by molecular modeling as potential transitionstateinhibitors of human glycosyltransferase I (GnT-I) [12], the bisubstrate enzyme requiring a metal co
PDF
Graphical Abstract
Figure 1:
Target ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones 1‒3.